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SERENE Relaxant / Sleep Aid Ingredients
St. John's wort (Hypericum perforatum), a yellow flowering plant native to Europe, has been used for centuries to heal wounds and calm frayed nerves, as an anti-inflammatory for strains, sprains, and contusions, and to treat muscular spasms, cramps, and tension that results in muscular spasms.
St. John's wort probably acts in the nervous system as an SSRI (selective serotonin reuptake inhibitor.) Although research is still ongoing, it is known that the pigment within the herb, known as hypericin and hyperforin (and other flavonoids) provides various therapeutic effects in the body (Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).
Nahrstedt A, Butterweck V. J Nat Prod. 2010 May 28;73(5):1015-21.). It is still the most common anti-depressant used in Europe.Please read the drug interactions warnings for St. John's wort.
Valerian has been used as a sleeping aid for hundreds of years. It is well known for its sedative qualities (A systematic review of insomnia and complementary medicine. Sarris J, Byrne GJ.), its ability to relax the central nervous system, and to calm smooth muscle (due to the valepotriates and the isovaleric acid.) At least two double-blind studies have demonstrated that valerian root extract can significantly reduce the amount of time it takes people to fall asleep without changing the normal stages of sleep.
Wild Jujube seed has been highly regarded by the Chinese for centuries for its supportive relaxation properties and extremely low toxicity. It is used throughout asia as the most popular sedative and calming agent. A number of compounds are present in jujube, including saponins, jujubosides and triterpenoic acids, but it appears that the saponins (and flavonoids) are the main active ingredients in terms of sedation and relaxation. Studies at the College of Food, South China University of Technology, investigated the sedative effects of the compounds extracted from jujube herb and orally administered to mice separately. Results show that flavonoids and saponins significantly prolonged time spent in deep sleep.
Magnolia Bark has been shown in numerous studies to support regulation and calming of the central-nervous-system. Along with magnolol, magnolia bark contains another active chemical called honokiol. According to researchers at Nanjing University in China (published in the Nov. 28 issue of Progress in Neuro-psychopharmacology and Biological Psychiatry,) the extracts from magnolia bark have significant antidepressant properties, as they help regulate brain chemicals that are associated with depression.
L-Theanine is an amino acid that is one of the main components of green tea. Research has shown that L-Theanine can significantly increase levels of GABA, a key brain chemical known for its calming effects, and dopamine, which effects mood.
L-Theanine readily crosses the blood-brain barrier of humans and exerts subtle changes in biochemistry. An increase in alpha waves has been documented (Relaxation and immunity enhancement effects of gamma-aminobutyric acid administration in humans. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H), and the effect has been compared to getting a massage or taking a hot bath. Research with human volunteers has demonstrated that L-Theanine creates its relaxing effect in approximately 30 to 40 minutes after ingestion. L-Theanine directly stimulates production of alpha brain waves, which creates a deep state of relaxation while maintaining mental alertness.
Beta-phenyl-gamma-aminobutyric acid (Phenibut) is a derivative of the neuro-transmitter GABA (gamma-amino butyric acid) that successfully crosses the blood-brain barrier, unlike GABA itself. Clinically, it has indicated supportive effects for anti-anxiety and muscle relaxation (Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks - Yoto A, Murao S, Motoki M, Yokoyama Y, Horie N, Takeshima K, Masuda K, Kim M, Yokogoshi H.).
Calcium and Magnesium deficiencies may produce muscle spasms and cramps, anxiety, nervousness, irritability, lack of sleep or restless sleep and physical fatigue (Study on selected trace elements and heavy metals in some popular medicinal plants from Sudan. Ebrahim AM, Eltayeb MH, Khalid H, Mohamed H, Abdalla W, Grill P, Michalke B).
So if you are experiencing muscle pain or discomfort, feel stressed, have insomnia or trouble getting a good nights rest, try SERENE, and wash the day away.
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SERENE should not be used by people with liver problems. |
General Warning:
All our products are natural nutritional supplements, and should be used as such. We make no health claims. Seek advice from a health professional prior to use if you are pregnant, or have high blood pressure, heart disease, thyroid disease, diabetes, difficulty in urination due to prostate enlargement, or are taking an MAO inhibitor or any other prescription drug. Reduce or discontinue use if nervousness, tremor, sleeplessness, loss of appetite, or nausea occur. Keep out of the reach of children.These statements have not been evaluated by the food and drug administration. The FDA Does not evaluate or test herbs. These products are not intended to diagnose, treat, cure or prevent any illness or disease. Consult with your physician for diagnosis or treatment. Use herbs as per instructions and always watch for any allergic reactions.
